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RxCheck – Replacement for the discontinued NLM drug interaction API

RxCheck – Replacement for the discontinued NLM drug interaction API

by bcfeen·Jun 3, 2026·1 point·0 comments

AI Analysis

●●SolidSolve My Problem

Direct NLM API replacement when no funded competitor filled the gap.

Strengths
  • RxNorm integration resolves brand, generic, and RxCUI identifiers correctly.
  • <50ms cached response time with structured JSON output.
  • Free tier with no credit card removes friction for testing.
Weaknesses
  • Aggregates public datasets without novel architecture or methodology.
  • Health API space has established players like First Databank and Micromedex.
Category
Target Audience

Healthcare developers, pharmacy app builders

Similar To

First Databank API · Micromedex Drug Interactions · NLM Drug Interaction API

Post Description

I built RxCheck as a replacement for the NLM Drug Interaction API which was discontinued in January 2024. It checks for interactions between any two drugs and returns severity, mechanism, and sources as JSON. It uses the DDInter 2.0 and the ONC high-priority list with RxNorm support. This is so all brand names, generics, and identifiers are still recognized. The free tier is 100 queries per month, no credit card required.

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