Genomi – make genome data manageable and queryable by AI agents

Hey HN, I’m Matthew, one of the people building Genomi.

Many people have done a DNA test or sequencing in the past, but the results stay virtually dead on our computer, maybe we saw a report that came with it, but does anyone still remember what it said? I don't. What bothers me even more is that the world of DNA science actually evolves quite quickly, there are many new findings published every year and that may or may not be relevant to your DNA, but your old report, which I spent a fair amount on, will not have it! (though it has gotten much much cheaper lately)

I feel AI agent is the perfect tool to help me query and understand my own DNA, but I am immediately hesitant to feed my own file to an agent, not only the security risk of sending my own DNA file to them, but it simply doesn't work, the massive nature of the file will overflow the context window with excess data that gives me near to no value. So we built Genomi: an open-source local genomics harness for AI agents.

Genomi parses a VCF/gVCF or supported consumer DNA export, such as 23andMe or AncestryDNA, into a local SQLite index called the Active Genome Index (AGI, heh). The agent does not need the whole genome in context. Instead, it calls tools against the local index and public evidence sources as it sees fit. Today it exposes 80+ evidence-focused tools across genomics sources including variant lookup, gene/disease evidence, pharmacogenomics, GWAS/PRS context, population context, sequence/region utilities, etc.

The project is at an early stage and I welcome any feedback, please let me know what you guys think!